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2.2 Regulation of glutathione metabolism Glutathione is synthesized in the cytosol of all animal cells by the regulated action of gamma-glutamate cysteine ligase (-GCL), glutathione synthetase, glutathione reductase (GSR), and gamma-glutamyl transpeptidase (-GGT) and from which it is distributed to the other cellular compartments [8]

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BioMed Research International, 2012, 153626

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If you are not sleeping well or are under constant stress, even the best antioxidants will have an uphill battle