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Cerebrolysin and morphine decrease glutathione and 5-hydroxyindole acetic acid levels in fasted rat brain

Compared to larger peptides, which often struggle with poor bioavailability and proteolytic degradation, tripeptides offer a balance of functional stability and conformational flexibility

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The laboratory version is engineered for stability in gastric acid, which is why so many rodent studies administer it orally or intraperitoneally and still report systemic effects