The bottom line GLP-1 facial aging appears to involve two mechanisms working at the same time: volume loss from rapid weight reduction, well-documented by the Sharma 2025 Vanderbilt study (PMID 40407186), and a separate cellular mechanism currently being characterized by the Paschou 2025 Endocrine review (PMID 40498168), the Ridha 2024 Aesthetic Surgery Journal paper (PMID 38874170), and the Semersky 2025 Aesthetic Surgery Journal Open Forum paper (doi:10.1093/asjof/ojaf030)
doi: 10.2170/physiolsci.RP002208 [DOI] [PubMed] [Google Scholar] 87
It works by mimicking the natural hormone GLP-1, enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety
Exercise: This is the time to get those gains in the gym
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Prescriptions are managed by board-certified physicians with dose customization, allowing adjustments for safety, tolerance, and long-term success
