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These can include:Skin rashes or irritationStomach upset or crampsAllergic reactions Because injections can be risky, the FDA and WHO do not recommend them for skin lightening

Completed Phase II and III clinical trials have indicated that the agent has a nonoverlapping toxicity profile and synergistic effects with carboplatin, paclitaxel, and anthracycline, has no cross-drug resistance and is well tolerated, with patients mostly reporting fatigue and nausea

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Some researchers suspect these drugs could influence the balance between bone formation and bone breakdown

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