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doi: 10.1289/EHP11343 20 ShimoiGWakabayashiRIshikawaRKameyamaY

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Cancer incidence in multiple sclerosis and effects of immunomodulatory treatments

43 Statistical analyses Within each region, biomarkers were evaluated using a multiple linear regression to test the group difference between cases and controls

It has been shown that HSYA was able to significantly protect the liver from oxidative stress by increasing the activities of antioxidant enzymes, upregulating the expression of PPAR- and MMP-2, and downregulating the expression of TGF-1 and tissue inhibitor of metalloproteinases-1 (TIMP-1), and reducing -SMA level, which indicating that PPAR-TGF-1 would be a signal pathways for HSYA to reduce liver fibrosis induced by oxidative stress (Wang et al., 2013)