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92 In vitro studies and gene expression analysis support the ability of PLLA to stimulate adipokine expression, type 4 and 6 collagen production, and greater adipogenesis compared to CaHA

GnRH agonists like leuprolide create a temporary menopause state, reducing pain in 85-90% of patients within 3 months, but bone loss limits use to 6-12 months without add-back therapy

In terms of selpercatinib, the [adverse] effects we watch out for are blood pressure elevation, sometimes liver function abnormalities, and some [gastrointestinal (GI) adverse] effects, and edema, but again, generally well-tolerated

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