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This distinction is why generic biologics are called biosimilars rather than generics. They are not chemically identical copies

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Alosetron should be stopped after 4 weeks if symptoms still exist, even if the dosage is increased to 1 mg twice a day (61)

10.1038/342440a0 Nature 130 NaldiniL.TamagnoneL.VignaE.SachsM.HartmannG.BirchmeierW.et al (1992)

In addition, other hormones such as glucagon, adiponectin, and growth hormone also contribute to thyroid regulation, although their role in KD is less well defined