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[34] In a head-to-head randomized trial, tirzepatide produced greater weight loss than semaglutide 2.4 mg in adults with obesity without diabetes

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But scientists are now finding out that the drug has other wide ranging, and less described, effects on the brain

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The 2024 semaglutide phase 2 RCT and the Weill Cornell cohort data are the most rigorous current evidence showing bone loss - but reasonable endocrinologists interpret even those findings with appropriate uncertainty about generalizability

In some cases, they may not be available in every strength or form as the brand name versions