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A proportion of pre-malignant lesions are present as either leucoplakia (white patches) or erythroplakia (red patches) which can progress to advanced stage of HNSCC

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Stability is a critical concern since excessive degradation may lead to subtherapeutic dosages, which can potentiate the selection of resistant pathogenic strains in the long term, therefore leading to treatment failure and economic loss (12, 25, 26)

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