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Lane et al

Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins, 24

First, FAs synergize with monosodium urate (MSU) crystals to amplify macrophage activation through TLR2/MyD88/NF-B and TLR4-MD2/MyD88/NF-B signaling, leading to NLRP3 inflammasome assembly and IL-1 maturation (93), AA metabolism in neutrophils drives the LTB4-BLT1-mediated chemotaxis and NETosis, amplifying local inflammation (78)

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Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: A prespecified analysis of the select trial