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The absence of glucagon-mediated metabolic activation means less thermogenic effect and potentially fewer early sleep disruptions

For women with insulin resistance, which is common in polycystic ovary syndrome (PCOS), prediabetes, and obesity, this effect is particularly meaningful

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The good news is that side effects are most common when you first begin taking semaglutide, and typically resolve and lessen with time as your body gets used to the medication