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Patients must also take a trial of phentermine, an older drug chemically related to amphetamines and still widely used for weight loss, before they can be approved for GLP-1s

However, patients who may be at higher risk for wet age-related macular degeneration, such as older adults, should be aware of the possibility of new visual symptoms. The exact reasons are unknown, but one explanation is that if blood sugar drops too quickly or too sharply in certain patients, this may unexpectedly affect the retina the light-sensitive tissue at the back of the eye, which contains GLP-1 receptors, the authors say

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[DOI] [Google Scholar] Prior, R

However, the precise mechanisms by which QCT ameliorates endothelial dysfunction in PE are not yet fully understood