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doi: 10.1016/j.peptides.2018.05.005 40 ZhangEXuFLiangHYanJXuHLiZet al

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RNK06138 reduces nuclear ERK5 and attenuates ERK5 Paradoxical activation Previous research has shown that ERK5 kinase inhibitors, including AX15836, can promote ERK5 nuclear translocation and activate ERK5 transcriptional activity, thus resulting in the paradoxical activation of kinase-independent functions upon pharmacological inhibition [40]

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[DOI] [PubMed] [Google Scholar] 286.Ekberg J.H., Hauge M., Kristensen L.V., Madsen A.N., Engelstoft M.S., Husted A.S