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Incidences of other toxicities were comparable across the three treatment groups in DURATION-8 (exenatide plus dapagliflozin, exenatide alone, and dapagliflozin alone, respectively), including pancreatitis (1.3%, 0.4%, and 0%), volume depletion (1.3%, 0.4%, and 2.1%), gastrointestinal events (20.8%, 23.9%, and 16.3%), and genital infections (5.2%, 2.2%, and 7.7%) [36]
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This beneficial action is peripherally and centrally, as well as centrally and peripherally, in rats with occluded major vessels peripherally and centrally or which underwent similar noxious procedures and various agents applications that all severely affect endothelium
