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A total of two kinases, ib kinase (IKK) and recombinant tank binding kinase 1 (TBK1), are closely associated with obesity and inflammation and results from animal experiments demonstrated that the expression of IKK and TBK1 was upregulated in adipose tissue of diet-induced obese animals, but IR, obesity and adiposity were not observed in IKK and TBK1-deficient animals

Several bacteria exploit these dynamics to manipulate host cell survival and immunity

doi:10.1002/oby.23736 32

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2015;10(8):e0136204