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& Clemmensen, C

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To investigate the efficacy of semaglutide on the metabolic and inflammatory features, post-baseline changes were analyzed using an MMRM, with baseline diabetes status, baseline fibrosis stage and diabetes-by-fibrosis interaction as factors (HbA1c, fasting plasma glucose, homeostatic model assessment of insulin resistance, adipose tissue insulin resistance and non-high-density lipoprotein cholesterol could not be included in the diabetes-by-fibrosis interaction as factors) and baseline body weight and baseline value of the feature as covariates, all nested within visit

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The titration schedule exists specifically to minimize these

The weight management formulation uses higher doses specifically to optimize these anorectic effects, whereas diabetes-focused dosing prioritizes glycemic control with appetite suppression as a beneficial secondary effect