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GCL is considered the speed limiting enzyme of synthesis since overexpression of GS does not increase GSH levels while overexpression of GCL increases the synthesis of GSH (61) (Figure 3)

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Key Benefits Fades Hyperpigmentation: Glutathione inhibits melanin production at the source

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(ii) the -ketoglutarate dehydrogenase complex that catalyzes the conversion of -ketoglutarate to succinyl CoA, another important intermediate of the citric acid cycle