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ISCs are involved in electron transport, substrate binding, enzymatic catalysis and play critical roles in maintaining genomic stability since several DNA polymerases and helicases require interaction with ISCs for proper functioning

FIGURE 9 5.3.5 ROS promotes UPS-mediated acceleration of protein degradation The ubiquitin-proteasome system (UPS) is the primary protein degradation machinery in eukaryotic cells, responsible for removing misfolded, damaged, or excess proteins to maintain proteostasis and regulate key cellular processes including cell cycle and immune signaling (Peris-Moreno et al., 2021)

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