If these symptoms persist or intensify rather than improving over the first few weeks, consider whether thyroid overmedication might be contributing
Retatrutide decreased mean SBP by up to 12.1 mmHg in persons with overweight/obesity not having uncontrolled hypertension [50], improving on results reported for tirzepatide [51] and semaglutide [52]
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It is the body partially adapting to the GLP-1 signal