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The MTHFR gene provides instructions for making the MTHFR enzyme (methylenetetrahydrofolate reductase) that helps convert folate (vitamin B9) into its active form: L-methylfolate.* This active folate is the key ingredient in producing methyl groupstiny chemical tags that your body uses in dozens of reactions, including: DNA repair, neurotransmitter synthesis, hormone metabolism, cardiovascular support, and detoxification.* The whole process is called methylation, and without enough methyl groups, your bodys cellular cleanup crews start falling behind on their tasks.* Detox Pathways That Depend on Methylation Methylation affects detox in two major ways: Breaking Down Hormones Estrogen, for example, requires methylation for efficient breakdown and elimination

doi: 10.1093/plcell/koac237 43 SmithM

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Caron et al., Resveratrol Resveratrol, a natural polyphenol, is secreted by specific plants such as grapes and berries in response to stress conditions including infection, sunlight, and climate (Singh et al., 2015

There is very little blood-flow to this tissue in the body

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