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Cell 160:816827 Lafontan M (2005) Fat cells: afferent and efferent messages define new approaches to treat obesity

This targeted approach ensures that only the fat cells are affected, leaving other tissues unharmed

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The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight