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Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease Transgenic mice

Really drove home the point about consistency

1982;4:135-40 59 -Jirillo E ea

When the gut barrier function is damaged, bacteria and toxins can penetrate the intestinal wall and activate the immune system, leading to inflammation reactions, these inflammatory reactions can be transmitted to the brain through the gut-brain axis, causing nervous inflammation and cognitive dysfunction (Bajic et al., 2018