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Paulose-Ram R, Hirsch R, Dillon C, et al

Key features of CJC-1295 No DAC CJC-1295 No DAC / Modified GRF (1-29): Activates the GHRH receptor Stimulates GH release through endogenous pituitary signaling Does not use DAC-mediated albumin binding Has a much shorter duration of action Is more often discussed in research involving pulsatile GH release Why it matters: No DAC is generally used to model shorter GHRH-like signaling, while DAC is used to study prolonged GH-axis activation

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Published research has employed this analog to study myoblast differentiation, satellite cell activation, and skeletal muscle hypertrophy signaling in C2C12 cultures, as well as hepatocyte glucose uptake via GLUT4 translocation

It directly engages peripheral receptors without first altering hypothalamic pulses

The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats PMID: 11735244 Growth Horm IGF Res