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IGF1R deficiency reduces tumor growth, proliferation, inflammation and vascularization, and increases apoptosis after tumor heterotopic transplantation Since IGF1R has been implicated in the pathogenesis of lung cancer by facilitating metastasis, tumor-associated inflammation and immune checkpoint regulation [12, 16], we decided to assess whether IGF1R deficiency in the TME delays implantation and progression in a heterotopic LLC mouse model

Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain

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