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71 In HPP, deficiency or dysfunction of TNSALP disrupts the metabolism of PLP leading to alteration of both extracellular and intracellular PLP levels

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Research conducted by Xuemei Yuan and colleagues revealed that rats with prednisolone-induced OP displayed markedly increased plasma concentrations of lysophosphatidylcholine (LPC) and phosphatidylcholine (PC), linked to gut microbial metabolism

In addition, no parenteral formulation of these compounds is currently available, which may limit their use in the treatment of severe trauma