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Mechanistically, DAMPs interact with toll-like receptors (TLRs) and purinergic receptors on Kupffer cells, resulting in the secretion of pro-inflammatory mediators such as IL-6, IL-18, IFN-, TNF-, and Fas ligands, which further promote macrophage proliferation [54]

A 10mg vial becomes more economical at higher doses (1.0mg and above) where weekly consumption increases significantly

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