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The doses administered to the rats were calculated using the US Food and Drug Administration guidelines for human equivalence doses (HED), assuming a human weight of 60 kg (Nair et al., 2016)

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doi: 10.3390/nu12030605 25 ZhuBRenHXieFAnYWangYTanY

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They can provide a painless treatment experience and have controllable drug release performance 133

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