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IL-13 exerts its anti-angiogenic function via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway (90), and it also can reduce the death of chondrocytes to protect the cartilage from destruction probably because of the reduction of Fc gamma receptor I (FcRI) (91)

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In some embodiments, auris formulations or compositions described herein are controlled release formulations, and are administered at reduced dosing frequency compared to the current standard of care

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Garcia-Ruiz I, Solis-Munoz P, Fernandez-Moreira D, Grau M, Colina F, Munoz-Yague T, et al