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Beyond the regulation of food intake, body weight and energy expenditure, POMC neurons directly respond to certain types of fatty acids and control hepatic glucose production, insulin sensitivity, glucose and lipid metabolism, illustrating their critical role in overseeing whole body use of energy substrates and consequent involvement in metabolic disorders [98, 122,123,124,125,126]
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187 Low melatonin levels have been linked to insomnia, particularly in the elderly
berghei SPZs (10,000/20,000 per mouse, in 100 L PBS), administered at 10-day intervals
