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The I statistic was 99.21%, showed that about 99% of total variability in effect estimates must be due to real differences in studies as opposed to the sampling error, which is very high amount of heterogeneity.Besides, the approximate 2 standard of 0.1074 in the random-effects model is a reflection of the extent of this true variance in the effect sizes of the studies

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avoiding touching/scrubbing the treated skin

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