The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course
Gruppen EG, Garcia E, Connelly MA, Jeyarajah EJ, Otvos JD, Bakker SJ, Dullaart RP
For semaglutide and fibromyalgia, we need more rigorous studies that look at a variety of factors
Consider safety syringes if needlestick injury is a concern
Adderall can cause negative side effects, some of which can be serious
Venkatas J, Singh M (2022) Localized nano-mediated interleukin-12 gene therapy: promising candidate for cancer immunotherapeutics
