If the injection site hurts, it could be from injecting the medication while it is cold consider allowing your medication to come to room temperature before the injection
doi: 10.1016/j.jcmgh.2021.02.007, 132
MATERIALS AND METHODS Animals Male Wistar Albino rats (200250 g) randomly assigned, 10 rats per each experimental group, were used in all experiments
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However, such observations need to be considered as hypothesis generating, requiring testing in preclinical and clinical studies that confirm efficacy and ensure safety