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The AD-associated APOE4 allele has been reported to enhance lactate synthesis, thereby altering the metabolic milieu, and to sensitize astrocytes to inflammatory stimuli without overtly changing baseline transcriptomic profiles

Genetic variants can alter peptide receptor expression or peptide breakdown, so two people on the same protocol may see different results

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Denis, Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study., Redox Biology, Volume 6, 2015, Pages 198-205, ISSN 2213-2317