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Also exenatide is available in a once weekly version, in which the molecule is slowly liberated from a subcutaneously injected depot

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SAM is the methyl donor for DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) that maintain methylation patterns at CpG sites, and for the histone methyltransferases (EZH2, SETD2, NSD2) that methylate histones to regulate chromatin state and gene expression

it can cause chemical irritation, tissue damage, or mask changes that need clinical monitoring

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