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Caspase-8, for instance, is able to directly cleave pro-IL-1, thus activating (and not inhibiting), through signal transduction, the necroptotic pathway, which is known to culminate in cell lysis accompanied with inflammation [128]

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In addition, metformin aggravates renal toxicity by promoting the neutrophil extracellular trap (NETosis) response and enhancing renal ferroptosis (Cai et al., 2023)

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Secondly, it prevents our body from oxidative stress caused by free radicals