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Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter

Laforge et al., 2020

doi: 10.1007/s00264-006-0087-x

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Two generations were raised, and no effects were observed on number or size of litters, survival or growth rate of offspring, urinalysis, haematology, hepatic and renal function, physical structure, or calcium and phosphorus content of the femoral bone, or in appearance during gross and microscopic examination

Additionally, the potential for low blood sugar and muscle loss due to rapid weight loss requires vigilant monitoring and management