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This includes upregulation of ATM by 80% in breast cancer cells and 120% in prostate cells

doi: 10.1152/ajplung.00175.2013 77 BaileyKLKharbandaKKKatafiaszDMSissonJHWyattTA

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A decrease in this ratio indicates increased oxidative stress, potentially triggering stress response programs such as apoptosis, necrosis, or autophagy