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Animal research used roughly 2-10 mcg/kg body weight orally

While GLP-1 receptor agonists like semaglutide work primarily through the GLP-1 pathway, cagrilintide targets a different but complementary satiety system

Among them are modulation of inflammation, promotion of angiogenesis, enhancement of matrix remodeling and activation of repair-linked transcription programs

This makes dose escalation intuitive

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist