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R., Aritas, Y

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Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application

Drawing a conclusion that subcutaneous semaglutide is associated with worsening of DR from this paper alone is thus premature

Not a huge difference on paper, but clinically significant for both efficacy and side effects

Microdosing is when you take smaller doses of the drug than prescribed