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However, their ability to cause severe intestinal and nephrotoxicity initiates burden on the patients life quality

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Apart from receptor-mediated targeting, the enhanced permeability and retention (EPR) effect, or increased permeability and retention of nanoparticles, is also an efficient means by which nanoparticles localize in the tumour area because of the peculiarities of its vascularization and lack of efficient lymphatics [300]

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