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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Block, Krysta Rodriguez, Dene Benton, Julia Lester, Sebastian Arcelus, Montego Glover, Diane Phelan, and Joaquina Kalukango

Do , bn cn duy tr gic ng ngon nhm phc hi sc khe, t gip duy tr hoc tng mc L-glutathione

Instrumental variables were identified as single nucleotide polymorphisms linked to the exposure, and analyses utilized inverse variance weighting as the primary method, followed by sensitivity assessments

Conclusions Ultimately, the current maintenance dose of 1,000 mcg B12 every 3 months may confer long term harm, therefore it seems that once B12 levels are stabilised well within acceptable range, then the standard B12 intervention of 1000 mcg should be administered annually, and monitored with pre-injection annual testing of levels

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