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Some of the potential risks of coffee enema include: Dehydration

It also protects cancer cells from apoptosis by induction of anti-apoptotic proteins, such as BCL2, BCLxL, XIAP, and so on [60, 63, 64]

1 2 "Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses"

Instead, the copper ion becomes integrated into the molecular structure of the peptide, producing a defined coordination environment

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Animal studies at effective doses showed no overt toxicity, but this cannot be extrapolated to human safety