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Instead of relying on passive absorption, they use arrays of dissolving microscopic needles (100 to 800 micrometers) that physically pierce the stratum corneum and release drug directly into the dermis

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For some people, the benefits of these medications do not outweigh the risks, as with any other pharmacologic intervention (e.g., adults who have previously had medullary thyroid cancer, in which they are contraindicated)

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