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The participants in the study were instructed to attain a calorie deficit of 1500 kcal in females and 1800 kcal in males per day

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Currently, tirzepatide is the clear choice for type 2 diabetes because it has FDA approval for this indication and extensive clinical evidence

Tirzepatide dosing protocol Tirzepatide follows a well-established escalation schedule refined through multiple clinical trials and years of real-world use: Weeks 1-4: 2.5 mg once weekly (starting dose) Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly (optional intermediate step) Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly (optional intermediate step) Week 21+: 15 mg once weekly (maximum dose) The starting dose of 2.5 mg is intentionally subtherapeutic

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