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21 Although the long-term retinal effects of GLP-1RA in DR arent fully understood at this time, an ongoing trial is investigating the extended effect of semaglutide on DR after 5 years of treatment

Folate deficiency in a mother increases the risk of neural tube defects including spina bifida, but the link to autism is unclear

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Genes involved in oxidative stress and ferroptosis modulate sensitivity, with GPX4 as the top sensitiser in both screens

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Nevertheless, GLP-1 RAs have gastrointestinal adverse effects such as abdominal pain, constipation, diarrhea, nausea, and vomiting [7]