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Overall, similar improvements in body weight parameters were observed among participants with WHO/IEC-defined prediabetes (Figure S3B and Figure S4)

However, keep in mind this benefit was seen in animals and has not yet been studied in humans

Clinical Evidence and Case Observations: What Research Shows Current evidence is mixed

Patients concerned about muscle preservation should prioritize these interventions and consider body composition assessment (such as DEXA scanning when available and covered by insurance) as an optional monitoring tool beyond simple weight measurement

, & Jerlhag, E

This enhanced monitoring ensures both medications remain in therapeutic ranges and that no unexpected interactions are emerging