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A 6-h treatment with thioacetamide led to a significant increase in ROS levels compared with the control group, but pre-treatment with 2APB effectively mitigated this oxidative stress in the liver of both wild-type and hepsin / mice
The Kyoto Prefectural University of Medicine Animal Care Committee approved all experimental protocols (permission numbers M2023-41)
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Once the oxygen starvation is initiated by DHT, the energy production within the cells in the hypoxic area is also shut down