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The progenitor basis of cortical projection neuron diversity

However, it is not certain that the 8.8 kb Hdc enhancer is fully responsible for positive regulation of the Hdc gene, because in vivo importance of the +0.3 kb Hdc enhancer in Hdc gene transcription cannot be ruled out by the luciferase reporter gene transcription assay alone ( Despite remarkable progress in genome-wide annotation of potential enhancers, functional validation of annotated enhancers remains an unmet challenge

Clin Pharmacol Ther 55(6):681692

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