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Atkuri KR et al

Remarkably, hyperactive neurons release excess fatty acids via ApoEcontaining lipoproteins, which astrocytes then detoxify by upregulating lipidperoxidation enzymes

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Multi-omics integration revealed a high-inflammation, high-oxidation, low-metabolism triad, which is mainly regulated by the Stat1-(2-carboxypropyl)-Cysteamine-C3 interaction axis

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Acknowledgements We thank all participating authors for their efforts