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After the initial stimulation, glucagon secretion returned to the pre-stimulatory level and subsequently raising the AAs to 6 mmol/l was without stimulatory effect (ESM Fig

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Apoptosis mainly works in synergy through the mitochondrial pathway (the upregulation of Bax/Bak and downregulation of Bcl-2 expressions leading to cytochrome C release), the death receptor pathway (the activation of caspase-8 mediated by Fas/FasL), and the ERS pathway (the inhibition of anti-apoptotic protein expression by the PKR-like endoplasmic reticulum kinase-C/EBP homologous protein (PERK-CHOP) pathway (Wang et al., 2022b

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